![]() We demonstrated an important role of CCR2-CCL2 axis in modulating T cell function which is one of the mechanisms of the prophylactic effect of MSCs on IPS. The prophylactic effect of MSCs on IPS was significantly attenuated by the administration of CCR2 or CCL2 antagonist in MSC-treated mice. ![]() Activation of CCR2-CCL2 axis and production of CCR2 +CD4 + T cells were observed in the lungs treated with MSCs. In IPS mouse model, application of MSCs prolonged the survival and reduced the pathological damage and T cell infiltration into lung tissue. ![]() Blocking CCR2-CCL2 interaction abolished the immunoregulatory effect of MSCs, leading to re-activation of T cells and partial reversion of polarizing toward CCR2 +CD4 + T cells. ResultsĬo-culture of pre-activated T cells with MSCs in vitro modulated the CCR2-CCL2 axis, resulting in quiescent T cells and polarization toward CCR2 +CD4 + T cell subsets. By establishing an IPS mouse model and administering MSCs to further verify the results of in vitro experiments. MethodsĬo-cultured pre-activated T cells and MSCs in vitro to observe the changes in the CCR2-CCL2 axis. Our previous study demonstrated that mesenchymal stem cells (MSCs) can alleviate IPS, but the mechanisms remain unclear. Safe and effective treatments are not yet available and under explorations. Conventional immunosuppressive treatments for IPS have poor therapeutic effects. ![]() Idiopathic pneumonia syndrome (IPS) is a non-infectious fatal complication characterized by a massive infiltration of leukocytes in lungs and diffuse pulmonary injury after allogeneic hematopoietic stem cell transplantation (allo-HSCT). ![]()
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January 2023
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